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BrianTwelo
22 Dezember 2019 16:59 | Nepal





The first satellite designed to continuously monitor the planet for methane leaks made a startling discovery last year: A little known gas-well accident at an Ohio fracking site was in fact one of the largest methane leaks ever recorded in the United States.
The findings by a Dutch-American team of scientists, published Monday in the Proceedings of the National Academy of Sciences, mark a step forward in using space technology to detect leaks of methane, a potent greenhouse gas that contributes to global warming, from oil and gas sites worldwide.
The scientists said the new findings reinforced the view that methane releases like these, which are difficult to predict, could be far more widespread than previously thought.
Were entering a new era. With a single observation, a single overpass, were able to see plumes of methane coming from large emission sources, said Ilse Aben, an expert in satellite remote sensing and one of the authors of the new research. Thats something totally new that we were previously not able to do from space.
Scientists also said the new findings reinforced the view that methane emissions from oil installations are far more widespread than previously thought.
The blowout, in February 2018 at a natural gas well run by an Exxon Mobil subsidiary in Belmont County, Ohio, released more methane than the entire oil and gas industries of many nations do in a year, the research team found. The Ohio episode triggered about 100 residents within a 1-mile radius to evacuate their homes while workers scrambled to plug the well.
At the time, the Exxon subsidiary, XTO Energy, said it could not immediately determine how much gas had leaked. But the European Space Agency had just launched a satellite with a new monitoring instrument called Tropomi, designed to collect more accurate measurements of methane.
We said, Can we see it? Lets look, said Steven Hamburg, a New York-based scientist with the Environmental Defense Fund, which had been collaborating on the satellite project with researchers at the Netherlands Institute for Space Research in Utrecht, the Netherlands.
Natural gas production has come under increased scrutiny because of the prevalence of leaks of methane the colorless, odorless main component of natural gas from the fuels supply chain.
When burned for electricity, natural gas is cleaner than coal, producing about half the carbon dioxide that coal does. But if methane escapes into the atmosphere before being burned, it can warm the planet more than 80 times as much as the same amount of carbon dioxide over a 20-year period.
The satellites measurements showed that, in Ohio in the 20 days it took for Exxon to plug the well, about 120 metric tons of methane an hour were released. That amounted to twice the rate of the largest known methane leak in the United States, from an oil and gas storage facility in Aliso Canyon, Calif., in 2015, though that event lasted longer and had higher emissions overall.
The Ohio blowout released more methane than the reported emissions of the oil and gas industries of countries like Norway and France, the researchers estimated. Scientists said the measurements from the Ohio site could mean that other large leaks are going undetected.
When I started working on methane, now about a decade ago, the standard line was: Weve got it under control. Were managing it, Hamburg said. But in fact, they didnt have the data. They didnt have it under control, because they didnt understand what was actually happening. And you cant manage what you dont measure.
An Exxon spokesman, Casey Norton, said that the companys own scientists had scrutinized images and taken pressure readings from the well to arrive at a smaller estimate of the emissions from the blowout. Exxon is in touch with the satellite researchers, Norton said, and has agreed to sit down and talk further to understand the discrepancy and see if theres anything that we can learn.
This was an anomaly, he said. This is not something that happens on any regular basis. And we do our very best to prevent this from ever happening.
An internal investigation found that high pressure had caused the wells casing, or internal lining, to fail, Norton said. After working with Ohio regulators on safety improvements, he said, the well is now in service.
Miranda Leppla, head of energy policy at the Ohio Environmental Council, said there had been complaints about health issues throat irritation, dizziness, breathing problems among residents closest to the well.
Methane emissions, unfortunately, arent a rare occurrence, but a constant threat that exacerbates climate change and can damage the health of Ohioans, she said.
Scientists said that a critical task was now to be more quickly able to sift through the tens of millions of data points the satellite collects each day to identify methane hot spots. Studies of oil fields in the United States have shown that a small number of sites with high emissions are responsible for the bulk of methane releases.
So far, detecting and measuring methane leaks has involved expensive field studies using aircraft and infrared cameras that make the invisible gas visible. In a visual investigation published last week, The New York Times used airborne measurement equipment and advanced infrared cameras to expose six so-called super emitters in a West Texas oil field.
In a separate paper published in October, researchers detailed the use of two satellites to detect and measure a longer-term leak of methane from a natural gas compressor station in Turkmenistan, in Central Asia. Researchers estimated emissions from the site to be roughly comparable to the overall release from the Aliso Canyon event.
The leak has now stopped, satellite readings show, after the researchers raised the alarm through diplomatic channels.
Thats the strength of satellites. We can look almost everywhere in the world, said Aben, a senior scientist at the Dutch space institute in Utrecht and an author on both papers.
(booklet printing printing in China).
There are limitations to hunting for methane leaks with satellite technology. Satellites cannot see beneath clouds. Scientists must also do complex calculations to account for the background methane that already exists in the earths atmosphere.
Still, satellites will increasingly be able to both rapidly detect large releases and shed light on the rise in methane levels in the atmosphere, which has been particularly pronounced since 2007 for reasons that still arent fully understood. Fracking natural-gas production, which accelerated just as atmospheric methane levels jumped, has been studied as one possible cause.
Right now, you have one-off reports, but we have no estimate globally of how frequently these things happen, Hamburg of the Environmental Defense Fund said. Is this a once a year kind of event? Once a week? Once a day? Knowing that will make a big difference in trying to fully understand what the aggregate emissions are from oil and gas.
The findings by a Dutch-American team of scientists, published Monday in the Proceedings of the National Academy of Sciences, mark a step forward in using space technology to detect leaks of methane, a potent greenhouse gas that contributes to global warming, from oil and gas sites worldwide.
The scientists said the new findings reinforced the view that methane releases like these, which are difficult to predict, could be far more widespread than previously thought.
Were entering a new era. With a single observation, a single overpass, were able to see plumes of methane coming from large emission sources, said Ilse Aben, an expert in satellite remote sensing and one of the authors of the new research. Thats something totally new that we were previously not able to do from space.
Scientists also said the new findings reinforced the view that methane emissions from oil installations are far more widespread than previously thought.
The blowout, in February 2018 at a natural gas well run by an Exxon Mobil subsidiary in Belmont County, Ohio, released more methane than the entire oil and gas industries of many nations do in a year, the research team found. The Ohio episode triggered about 100 residents within a 1-mile radius to evacuate their homes while workers scrambled to plug the well.
At the time, the Exxon subsidiary, XTO Energy, said it could not immediately determine how much gas had leaked. But the European Space Agency had just launched a satellite with a new monitoring instrument called Tropomi, designed to collect more accurate measurements of methane.
We said, Can we see it? Lets look, said Steven Hamburg, a New York-based scientist with the Environmental Defense Fund, which had been collaborating on the satellite project with researchers at the Netherlands Institute for Space Research in Utrecht, the Netherlands.
Natural gas production has come under increased scrutiny because of the prevalence of leaks of methane the colorless, odorless main component of natural gas from the fuels supply chain.
When burned for electricity, natural gas is cleaner than coal, producing about half the carbon dioxide that coal does. But if methane escapes into the atmosphere before being burned, it can warm the planet more than 80 times as much as the same amount of carbon dioxide over a 20-year period.
The satellites measurements showed that, in Ohio in the 20 days it took for Exxon to plug the well, about 120 metric tons of methane an hour were released. That amounted to twice the rate of the largest known methane leak in the United States, from an oil and gas storage facility in Aliso Canyon, Calif., in 2015, though that event lasted longer and had higher emissions overall.
The Ohio blowout released more methane than the reported emissions of the oil and gas industries of countries like Norway and France, the researchers estimated. Scientists said the measurements from the Ohio site could mean that other large leaks are going undetected.
When I started working on methane, now about a decade ago, the standard line was: Weve got it under control. Were managing it, Hamburg said. But in fact, they didnt have the data. They didnt have it under control, because they didnt understand what was actually happening. And you cant manage what you dont measure.
An Exxon spokesman, Casey Norton, said that the companys own scientists had scrutinized images and taken pressure readings from the well to arrive at a smaller estimate of the emissions from the blowout. Exxon is in touch with the satellite researchers, Norton said, and has agreed to sit down and talk further to understand the discrepancy and see if theres anything that we can learn.
This was an anomaly, he said. This is not something that happens on any regular basis. And we do our very best to prevent this from ever happening.
An internal investigation found that high pressure had caused the wells casing, or internal lining, to fail, Norton said. After working with Ohio regulators on safety improvements, he said, the well is now in service.
Miranda Leppla, head of energy policy at the Ohio Environmental Council, said there had been complaints about health issues throat irritation, dizziness, breathing problems among residents closest to the well.
Methane emissions, unfortunately, arent a rare occurrence, but a constant threat that exacerbates climate change and can damage the health of Ohioans, she said.
Scientists said that a critical task was now to be more quickly able to sift through the tens of millions of data points the satellite collects each day to identify methane hot spots. Studies of oil fields in the United States have shown that a small number of sites with high emissions are responsible for the bulk of methane releases.
So far, detecting and measuring methane leaks has involved expensive field studies using aircraft and infrared cameras that make the invisible gas visible. In a visual investigation published last week, The New York Times used airborne measurement equipment and advanced infrared cameras to expose six so-called super emitters in a West Texas oil field.
In a separate paper published in October, researchers detailed the use of two satellites to detect and measure a longer-term leak of methane from a natural gas compressor station in Turkmenistan, in Central Asia. Researchers estimated emissions from the site to be roughly comparable to the overall release from the Aliso Canyon event.
The leak has now stopped, satellite readings show, after the researchers raised the alarm through diplomatic channels.
Thats the strength of satellites. We can look almost everywhere in the world, said Aben, a senior scientist at the Dutch space institute in Utrecht and an author on both papers.
(booklet printing printing in China).
There are limitations to hunting for methane leaks with satellite technology. Satellites cannot see beneath clouds. Scientists must also do complex calculations to account for the background methane that already exists in the earths atmosphere.
Still, satellites will increasingly be able to both rapidly detect large releases and shed light on the rise in methane levels in the atmosphere, which has been particularly pronounced since 2007 for reasons that still arent fully understood. Fracking natural-gas production, which accelerated just as atmospheric methane levels jumped, has been studied as one possible cause.
Right now, you have one-off reports, but we have no estimate globally of how frequently these things happen, Hamburg of the Environmental Defense Fund said. Is this a once a year kind of event? Once a week? Once a day? Knowing that will make a big difference in trying to fully understand what the aggregate emissions are from oil and gas.
arguh
19 Dezember 2019 23:11 | Lebanon





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SimaTig
18 Dezember 2019 10:25 | Russia





Π§ΡΠΎΠ±Ρ Π²ΡΠ»Π΅ΡΠΈΡΡ ΡΠ°ΠΊ, ΡΡΠ΅Π±ΡΠ΅ΡΡΡ Π΄ΠΎΡΠΎΠ³ΠΎΡΡΠΎΡΡΠ΅Π΅ ΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅
Π»Π΅ΡΠ΅Π½ΠΈΠ΅.
ΠΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½Ρ ΠΡΠ°Π»ΠΊΠΎΡΠΈ (Crizotinib) - Xalkori (ΠΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±)
ΠΏΡΠ΅Π΄Π½Π°Π·Π½Π°ΡΠ΅Π½ Π΄Π»Ρ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»ΡΠ³ΠΊΠΈΡ . ΠΠΎΠ²Π΅ΠΉΡΠ΅Π΅ ΡΡΠ΅Π΄ΡΡΠ²ΠΎ ΡΡΠΏΠ΅Π»ΠΎ ΠΎΡΠ»ΠΈΡΠ½ΠΎ Π·Π°ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΠΎΠ²Π°ΡΡ ΡΠ΅Π±Ρ Π² ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠ΅ΡΡΡΠ·Π½ΠΎΠ³ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ.
Π‘ΠΎΡΡΠ°Π² ΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°
Π ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π³ΠΎ ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΡ Π²Ρ ΠΎΠ΄ΠΈΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΠ΅
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ΅ Π²Π΅ΡΠ΅ΡΡΠ²ΠΎ ΠΊΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±, ΠΊΠΎΡΠΎΡΠΎΠ΅ ΡΠ²Π»ΡΠ΅ΡΡΡ
ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠΌ ΡΠΈΡΠΎΠ·ΠΈΠ½ΠΊΠΈΠ½Π°Π·Ρ ΠΈ ΠΊΠΈΠ½Π°Π·Ρ Π°Π½Π°ΠΏΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ
Π»ΠΈΠΌΡΠΎΠΌΡ.
Π’Π°ΠΊΠΆΠ΅ Π² ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ Π²Π΅ΡΠ΅ΡΡΠ²Π°,
ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΡΡ Π»ΡΡΡΠ΅ΠΉ Π°Π±ΡΠΎΡΠ±ΡΠΈΠΈ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ
Π²Π΅ΡΠ΅ΡΡΠ²Π°.
ΠΠ΅ΠΊΠ°ΡΡΡΠ²ΠΎ ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π³ΠΎ ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΡ ΠΏΡΠ΅ΠΊΡΠ°ΡΠ°Π΅Ρ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅
Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΎΠΏΡΡ ΠΎΠ»ΠΈ ΠΈ ΡΠ±ΠΈΠ²Π°Π΅Ρ ΡΠ°ΠΊΠΎΠ²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ.
Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΡΠ΅Π΄ΡΡΠ²Π° ΠΏΡΠΎΠΈΡΡ ΠΎΠ΄ΠΈΡ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅
ΠΊΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±ΠΎΠΌ ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΡΡΡΡΠΊΡΡΡ.
ΠΡΠ΅ΠΏΠ°ΡΠ°Ρ ΠΡΠ°Π»ΠΊΠΎΡΠΈ β ΠΌΠΎΡΠ½ΠΎΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠ΅ ΡΡΠ΅Π΄ΡΡΠ²ΠΎ,
ΠΊΠΎΡΠΎΡΠΎΠ΅ ΡΠ°ΡΡΠΎ Π½Π°Π·Π½Π°ΡΠ°Π΅ΡΡΡ Π²ΡΠ°ΡΠ°ΠΌΠΈ, Π΅ΡΠ»ΠΈ ΠΏΡΠ΅Π΄ΡΠ΄ΡΡΠ΅Π΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅
ΡΠ°ΠΊΠ° Π»ΡΠ³ΠΊΠΈΡ Π½Π΅ ΠΏΡΠΈΠ½Π΅ΡΠ»ΠΎ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°.
ΠΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠ΅ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΡΡΠ΅Π΄ΡΡΠ²Π° ΡΠ²Π»ΡΠ΅ΡΡΡ Π΄ΠΎΠ·ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΡΠΌ.
Π§ΡΠΎΠ±Ρ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½Ρ
ΠΡΠ°Π»ΠΊΠΎΡΠΈ (Crizotinib) - Xalkori (ΠΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±) ΠΊΡΠΏΠΈΡΡ ΠΏΠΎ ΡΠ½ΠΈΠΆΠ΅Π½Π½ΠΎΠΉ ΡΠ΅Π½Π΅, ΠΎΠ±ΡΠ°ΡΠ°ΠΉΡΠ΅ΡΡ Π² Π½Π°ΡΡ ΠΈΠ½ΡΠ΅ΡΠ½Π΅Ρ Π°ΠΏΡΠ΅ΠΊΡ.
ΠΠΎΠΊΠ°Π·Π°Π½ΠΈΡ
β’ ALK-ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΡΠΉ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΡΠ°ΠΊ; β’ ROS-1-ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΡΠΉ ΡΠ°ΠΊ Π»ΡΠ³ΠΊΠΎΠ³ΠΎ.
ΠΡΠΎΡΠΈΠ²ΠΎΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΡ
β’ Π³ΠΈΠΏΠ΅ΡΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΊ ΡΠΎΡΡΠ°Π²Ρ ΡΡΠ΅Π΄ΡΡΠ²Π°; β’ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΡ; β’ Π»Π°ΠΊΡΠ°ΡΠΈΡ; β’ Π΄Π΅ΡΡΠΊΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ;
β’ ΠΏΠ΅ΡΡΠ½ΠΎΡΠ½Π°Ρ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΡ; β’ ΡΠΎΠ²ΠΌΠ΅ΡΡΠ½ΡΠΉ ΠΏΡΠΈΡΠΌ Ρ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠ°ΠΌΠΈ CYP3A.
Π‘ΠΏΠΎΡΠΎΠ± ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ
ΠΡΠΈΡΠΌ Π΄Π°Π½Π½ΠΎΠ³ΠΎ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π° Π½Π΅ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΡΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΡ ΠΏΠΈΡΠΈ. ΠΠ°ΠΏΡΡΠ»Π° ΠΏΡΠΎΠ³Π»Π°ΡΡΠ²Π°Π΅ΡΡΡ,
Π½Π΅ ΡΠ°Π·ΠΆΡΠ²ΡΠ²Π°ΡΡΡ. Π’ΡΠ΅Π±ΡΠ΅ΡΡΡ Π½Π΅ΠΏΡΠ΅ΠΌΠ΅Π½Π½ΠΎ Π·Π°ΠΏΠΈΡΡ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½Ρ ΡΠΈΡΡΠΎΠΉ Π²ΠΎΠ΄ΠΎΠΉ.
ΠΠ΅Π΄ΠΈΠΊΠΈ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΡΡΡ Π΄ΠΎΠ·Ρ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° - 250 ΠΌΠ³ (2 ΡΠ°Π·Π° Π² ΡΡΡΠΊΠΈ).
ΠΠ΅ ΡΠ»Π΅Π΄ΡΠ΅Ρ ΡΠ΄Π²Π°ΠΈΠ²Π°ΡΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ Π΄ΠΎΠ·ΠΈΡΠΎΠ²ΠΊΡ ΠΏΡΠΈ ΠΏΡΠΎΠΏΡΡΠΊΠ΅ ΡΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΡ ΡΡΠ΅Π΄ΡΡΠ²Π°.
ΠΠΎΡΡΠ΅ΠΊΡΠΈΡ Π΄ΠΎΠ·Ρ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ CTCAE.
ΠΡΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΡ ΠΏΠΎΠ±ΠΎΡΠ½ΡΡ ΡΡΡΠ΅ΠΊΡΠ°Ρ Π»Π΅ΠΊΠ°ΡΡΡΠ²ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎ ΠΎΡΠΌΠ΅Π½ΡΠ΅ΡΡΡ.
ΠΠ΄Π½Π°ΠΊΠΎ Π½Π° ΡΡΠ΅Π΄ΡΡΠ²ΠΎ ΠΡΠ°Π»ΠΊΠΎΡΠΈ (Crizotinib) - Xalkori (ΠΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±) ΠΎΡΠ·ΡΠ²Ρ
Π²ΡΡΡΠ΅ΡΠ°ΡΡΡΡ Π»ΠΈΡΡ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠ΅. ΠΡΠ΅ΠΏΠ°ΡΠ°Ρ Ρ ΠΎΡΠΎΡΠΎ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠΈΡΡΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠΌ.
ΠΠΎΠ±ΠΎΡΠ½ΡΠ΅ ΡΠ΅Π°ΠΊΡΠΈΠΈ
β’ Π³ΠΎΠ»ΠΎΠ²ΠΎΠΊΡΡΠΆΠ΅Π½ΠΈΡ; β’ Π½Π΅ΠΉΡΠΎΠΏΠ°ΡΠΈΡ; β’ ΠΏΠΎΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π°ΠΏΠΏΠ΅ΡΠΈΡΠ°; β’ ΡΠΎΡΠ½ΠΎΡΠ°; β’ Π΄ΠΈΠ°ΡΠ΅Ρ; β’ Π·Π°ΠΏΠΎΡ;
β’ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π·ΡΠ΅Π½ΠΈΡ.
ΠΠ΄Π΅ ΠΊΡΠΏΠΈΡΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²ΠΎ
Π£ Π½Π°Ρ Π½Π° ΡΠ°ΠΉΡΠ΅ ΠΊΠ°ΠΆΠ΄ΡΠΉ ΠΏΠΎΠΊΡΠΏΠ°ΡΠ΅Π»Ρ ΠΌΠΎΠΆΠ΅Ρ ΠΊΡΠΏΠΈΡΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²ΠΎ ΠΏΠΎ ΠΏΡΠΈΠ΅ΠΌΠ»Π΅ΠΌΠΎΠΉ ΡΡΠΎΠΈΠΌΠΎΡΡΠΈ.
ΠΠ° ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½Ρ ΠΡΠ°Π»ΠΊΠΎΡΠΈ (Crizotinib) - Xalkori (ΠΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±) ΡΠ΅Π½Π° Π΄ΠΎΡΡΡΠΏΠ½Π° ΠΊΠ°ΠΆΠ΄ΠΎΠΌΡ
ΠΏΠΎΠΊΡΠΏΠ°ΡΠ΅Π»Ρ. ΠΡ ΠΌΠΎΠΆΠ΅ΡΠ΅ Π·Π°ΠΊΠ°Π·Π°ΡΡ Π΄ΠΎΡΡΠ°Π²ΠΊΡ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½ΡΠ° ΠΏΠΎ ΡΠΊΠ°Π·Π°Π½Π½ΠΎΠΌΡ Π½ΠΎΠΌΠ΅ΡΡ ΡΠ΅Π»Π΅ΡΠΎΠ½Π° Π»ΠΈΠ±ΠΎ
ΠΎΡΠΎΡΠΌΠΈΡΡ ΠΏΠΎΠΊΡΠΏΠΊΡ ΠΏΡΡΠΌΠΎ Π² ΡΠΎΡΠΌΠ΅ Π·Π°ΠΊΠ°Π·Π°. ΠΡΠ»ΠΈ Π²Π°ΠΌ ΡΡΠ΅Π±ΡΠ΅ΡΡΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²ΠΎ
ΠΡΠ°Π»ΠΊΠΎΡΠΈ (Crizotinib) - Xalkori (ΠΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±) ΡΡΠΎΠΈΠΌΠΎΡΡΡ Π² Π½Π°ΡΠ΅ΠΉ ΠΈΠ½ΡΠ΅ΡΠ½Π΅Ρ Π°ΠΏΡΠ΅ΠΊΠ΅
Π½Π°ΠΌΠ½ΠΎΠ³ΠΎ Π½ΠΈΠΆΠ΅, ΡΠ΅ΠΌ Π² Π΄ΡΡΠ³ΠΈΡ ΠΏΡΠ½ΠΊΡΠ°Ρ ΠΏΡΠΎΠ΄Π°ΠΆΠΈ. ΠΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½ΡΠ° Π½Π° Π½Π°ΡΠ΅ΠΌ
ΡΠ°ΠΉΡΠ΅ Π³Π°ΡΠ°Π½ΡΠΈΡΡΠ΅Ρ Π²Π°ΠΌ Π²ΡΡΠΎΠΊΠΎΠ΅ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ Π½ΡΠΆΠ½ΠΎΠ³ΠΎ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π° ΠΈ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡ Π΄Π΅Π½Π΅Π³.
ΠΡ ΠΌΠΎΠΆΠ΅ΡΠ΅ Π·Π°ΠΊΠ°Π·Π°ΡΡ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎΠ΅ Π»Π΅ΠΊΠ°ΡΡΡΠ²ΠΎ, Π½Π΅ Π²ΡΡ ΠΎΠ΄Ρ ΠΈΠ· Π΄ΠΎΠΌΠ°, ΠΏΡΡΠΌΠΎ ΡΠ΅ΠΉΡΠ°Ρ!
ΠΊΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ± +ΠΊΠ°ΠΊ Π²ΡΠΏΠΈΡΠ°ΡΡ ΡΠ΅ΡΠ΅ΠΏΡ
Π»Π΅ΡΠ΅Π½ΠΈΠ΅.
ΠΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½Ρ ΠΡΠ°Π»ΠΊΠΎΡΠΈ (Crizotinib) - Xalkori (ΠΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±)
ΠΏΡΠ΅Π΄Π½Π°Π·Π½Π°ΡΠ΅Π½ Π΄Π»Ρ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»ΡΠ³ΠΊΠΈΡ . ΠΠΎΠ²Π΅ΠΉΡΠ΅Π΅ ΡΡΠ΅Π΄ΡΡΠ²ΠΎ ΡΡΠΏΠ΅Π»ΠΎ ΠΎΡΠ»ΠΈΡΠ½ΠΎ Π·Π°ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΠΎΠ²Π°ΡΡ ΡΠ΅Π±Ρ Π² ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠ΅ΡΡΡΠ·Π½ΠΎΠ³ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ.
Π‘ΠΎΡΡΠ°Π² ΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°
Π ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π³ΠΎ ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΡ Π²Ρ ΠΎΠ΄ΠΈΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΠ΅
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ΅ Π²Π΅ΡΠ΅ΡΡΠ²ΠΎ ΠΊΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±, ΠΊΠΎΡΠΎΡΠΎΠ΅ ΡΠ²Π»ΡΠ΅ΡΡΡ
ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠΌ ΡΠΈΡΠΎΠ·ΠΈΠ½ΠΊΠΈΠ½Π°Π·Ρ ΠΈ ΠΊΠΈΠ½Π°Π·Ρ Π°Π½Π°ΠΏΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ
Π»ΠΈΠΌΡΠΎΠΌΡ.
Π’Π°ΠΊΠΆΠ΅ Π² ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ Π²Π΅ΡΠ΅ΡΡΠ²Π°,
ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΡΡ Π»ΡΡΡΠ΅ΠΉ Π°Π±ΡΠΎΡΠ±ΡΠΈΠΈ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ
Π²Π΅ΡΠ΅ΡΡΠ²Π°.
ΠΠ΅ΠΊΠ°ΡΡΡΠ²ΠΎ ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π³ΠΎ ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΡ ΠΏΡΠ΅ΠΊΡΠ°ΡΠ°Π΅Ρ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅
Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΎΠΏΡΡ ΠΎΠ»ΠΈ ΠΈ ΡΠ±ΠΈΠ²Π°Π΅Ρ ΡΠ°ΠΊΠΎΠ²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ.
Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΡΠ΅Π΄ΡΡΠ²Π° ΠΏΡΠΎΠΈΡΡ ΠΎΠ΄ΠΈΡ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅
ΠΊΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±ΠΎΠΌ ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΡΡΡΡΠΊΡΡΡ.
ΠΡΠ΅ΠΏΠ°ΡΠ°Ρ ΠΡΠ°Π»ΠΊΠΎΡΠΈ β ΠΌΠΎΡΠ½ΠΎΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠ΅ ΡΡΠ΅Π΄ΡΡΠ²ΠΎ,
ΠΊΠΎΡΠΎΡΠΎΠ΅ ΡΠ°ΡΡΠΎ Π½Π°Π·Π½Π°ΡΠ°Π΅ΡΡΡ Π²ΡΠ°ΡΠ°ΠΌΠΈ, Π΅ΡΠ»ΠΈ ΠΏΡΠ΅Π΄ΡΠ΄ΡΡΠ΅Π΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅
ΡΠ°ΠΊΠ° Π»ΡΠ³ΠΊΠΈΡ Π½Π΅ ΠΏΡΠΈΠ½Π΅ΡΠ»ΠΎ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°.
ΠΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠ΅ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΡΡΠ΅Π΄ΡΡΠ²Π° ΡΠ²Π»ΡΠ΅ΡΡΡ Π΄ΠΎΠ·ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΡΠΌ.
Π§ΡΠΎΠ±Ρ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½Ρ
ΠΡΠ°Π»ΠΊΠΎΡΠΈ (Crizotinib) - Xalkori (ΠΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±) ΠΊΡΠΏΠΈΡΡ ΠΏΠΎ ΡΠ½ΠΈΠΆΠ΅Π½Π½ΠΎΠΉ ΡΠ΅Π½Π΅, ΠΎΠ±ΡΠ°ΡΠ°ΠΉΡΠ΅ΡΡ Π² Π½Π°ΡΡ ΠΈΠ½ΡΠ΅ΡΠ½Π΅Ρ Π°ΠΏΡΠ΅ΠΊΡ.
ΠΠΎΠΊΠ°Π·Π°Π½ΠΈΡ
β’ ALK-ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΡΠΉ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΡΠ°ΠΊ; β’ ROS-1-ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΡΠΉ ΡΠ°ΠΊ Π»ΡΠ³ΠΊΠΎΠ³ΠΎ.
ΠΡΠΎΡΠΈΠ²ΠΎΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΡ
β’ Π³ΠΈΠΏΠ΅ΡΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΊ ΡΠΎΡΡΠ°Π²Ρ ΡΡΠ΅Π΄ΡΡΠ²Π°; β’ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΡ; β’ Π»Π°ΠΊΡΠ°ΡΠΈΡ; β’ Π΄Π΅ΡΡΠΊΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ;
β’ ΠΏΠ΅ΡΡΠ½ΠΎΡΠ½Π°Ρ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΡ; β’ ΡΠΎΠ²ΠΌΠ΅ΡΡΠ½ΡΠΉ ΠΏΡΠΈΡΠΌ Ρ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠ°ΠΌΠΈ CYP3A.
Π‘ΠΏΠΎΡΠΎΠ± ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ
ΠΡΠΈΡΠΌ Π΄Π°Π½Π½ΠΎΠ³ΠΎ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π° Π½Π΅ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΡΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΡ ΠΏΠΈΡΠΈ. ΠΠ°ΠΏΡΡΠ»Π° ΠΏΡΠΎΠ³Π»Π°ΡΡΠ²Π°Π΅ΡΡΡ,
Π½Π΅ ΡΠ°Π·ΠΆΡΠ²ΡΠ²Π°ΡΡΡ. Π’ΡΠ΅Π±ΡΠ΅ΡΡΡ Π½Π΅ΠΏΡΠ΅ΠΌΠ΅Π½Π½ΠΎ Π·Π°ΠΏΠΈΡΡ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½Ρ ΡΠΈΡΡΠΎΠΉ Π²ΠΎΠ΄ΠΎΠΉ.
ΠΠ΅Π΄ΠΈΠΊΠΈ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΡΡΡ Π΄ΠΎΠ·Ρ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° - 250 ΠΌΠ³ (2 ΡΠ°Π·Π° Π² ΡΡΡΠΊΠΈ).
ΠΠ΅ ΡΠ»Π΅Π΄ΡΠ΅Ρ ΡΠ΄Π²Π°ΠΈΠ²Π°ΡΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ Π΄ΠΎΠ·ΠΈΡΠΎΠ²ΠΊΡ ΠΏΡΠΈ ΠΏΡΠΎΠΏΡΡΠΊΠ΅ ΡΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΡ ΡΡΠ΅Π΄ΡΡΠ²Π°.
ΠΠΎΡΡΠ΅ΠΊΡΠΈΡ Π΄ΠΎΠ·Ρ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ CTCAE.
ΠΡΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΡ ΠΏΠΎΠ±ΠΎΡΠ½ΡΡ ΡΡΡΠ΅ΠΊΡΠ°Ρ Π»Π΅ΠΊΠ°ΡΡΡΠ²ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎ ΠΎΡΠΌΠ΅Π½ΡΠ΅ΡΡΡ.
ΠΠ΄Π½Π°ΠΊΠΎ Π½Π° ΡΡΠ΅Π΄ΡΡΠ²ΠΎ ΠΡΠ°Π»ΠΊΠΎΡΠΈ (Crizotinib) - Xalkori (ΠΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±) ΠΎΡΠ·ΡΠ²Ρ
Π²ΡΡΡΠ΅ΡΠ°ΡΡΡΡ Π»ΠΈΡΡ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠ΅. ΠΡΠ΅ΠΏΠ°ΡΠ°Ρ Ρ ΠΎΡΠΎΡΠΎ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠΈΡΡΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠΌ.
ΠΠΎΠ±ΠΎΡΠ½ΡΠ΅ ΡΠ΅Π°ΠΊΡΠΈΠΈ
β’ Π³ΠΎΠ»ΠΎΠ²ΠΎΠΊΡΡΠΆΠ΅Π½ΠΈΡ; β’ Π½Π΅ΠΉΡΠΎΠΏΠ°ΡΠΈΡ; β’ ΠΏΠΎΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π°ΠΏΠΏΠ΅ΡΠΈΡΠ°; β’ ΡΠΎΡΠ½ΠΎΡΠ°; β’ Π΄ΠΈΠ°ΡΠ΅Ρ; β’ Π·Π°ΠΏΠΎΡ;
β’ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π·ΡΠ΅Π½ΠΈΡ.
ΠΠ΄Π΅ ΠΊΡΠΏΠΈΡΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²ΠΎ
Π£ Π½Π°Ρ Π½Π° ΡΠ°ΠΉΡΠ΅ ΠΊΠ°ΠΆΠ΄ΡΠΉ ΠΏΠΎΠΊΡΠΏΠ°ΡΠ΅Π»Ρ ΠΌΠΎΠΆΠ΅Ρ ΠΊΡΠΏΠΈΡΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²ΠΎ ΠΏΠΎ ΠΏΡΠΈΠ΅ΠΌΠ»Π΅ΠΌΠΎΠΉ ΡΡΠΎΠΈΠΌΠΎΡΡΠΈ.
ΠΠ° ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½Ρ ΠΡΠ°Π»ΠΊΠΎΡΠΈ (Crizotinib) - Xalkori (ΠΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±) ΡΠ΅Π½Π° Π΄ΠΎΡΡΡΠΏΠ½Π° ΠΊΠ°ΠΆΠ΄ΠΎΠΌΡ
ΠΏΠΎΠΊΡΠΏΠ°ΡΠ΅Π»Ρ. ΠΡ ΠΌΠΎΠΆΠ΅ΡΠ΅ Π·Π°ΠΊΠ°Π·Π°ΡΡ Π΄ΠΎΡΡΠ°Π²ΠΊΡ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½ΡΠ° ΠΏΠΎ ΡΠΊΠ°Π·Π°Π½Π½ΠΎΠΌΡ Π½ΠΎΠΌΠ΅ΡΡ ΡΠ΅Π»Π΅ΡΠΎΠ½Π° Π»ΠΈΠ±ΠΎ
ΠΎΡΠΎΡΠΌΠΈΡΡ ΠΏΠΎΠΊΡΠΏΠΊΡ ΠΏΡΡΠΌΠΎ Π² ΡΠΎΡΠΌΠ΅ Π·Π°ΠΊΠ°Π·Π°. ΠΡΠ»ΠΈ Π²Π°ΠΌ ΡΡΠ΅Π±ΡΠ΅ΡΡΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²ΠΎ
ΠΡΠ°Π»ΠΊΠΎΡΠΈ (Crizotinib) - Xalkori (ΠΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±) ΡΡΠΎΠΈΠΌΠΎΡΡΡ Π² Π½Π°ΡΠ΅ΠΉ ΠΈΠ½ΡΠ΅ΡΠ½Π΅Ρ Π°ΠΏΡΠ΅ΠΊΠ΅
Π½Π°ΠΌΠ½ΠΎΠ³ΠΎ Π½ΠΈΠΆΠ΅, ΡΠ΅ΠΌ Π² Π΄ΡΡΠ³ΠΈΡ ΠΏΡΠ½ΠΊΡΠ°Ρ ΠΏΡΠΎΠ΄Π°ΠΆΠΈ. ΠΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½ΡΠ° Π½Π° Π½Π°ΡΠ΅ΠΌ
ΡΠ°ΠΉΡΠ΅ Π³Π°ΡΠ°Π½ΡΠΈΡΡΠ΅Ρ Π²Π°ΠΌ Π²ΡΡΠΎΠΊΠΎΠ΅ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ Π½ΡΠΆΠ½ΠΎΠ³ΠΎ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π° ΠΈ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡ Π΄Π΅Π½Π΅Π³.
ΠΡ ΠΌΠΎΠΆΠ΅ΡΠ΅ Π·Π°ΠΊΠ°Π·Π°ΡΡ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎΠ΅ Π»Π΅ΠΊΠ°ΡΡΡΠ²ΠΎ, Π½Π΅ Π²ΡΡ ΠΎΠ΄Ρ ΠΈΠ· Π΄ΠΎΠΌΠ°, ΠΏΡΡΠΌΠΎ ΡΠ΅ΠΉΡΠ°Ρ!
ΠΊΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ± +ΠΊΠ°ΠΊ Π²ΡΠΏΠΈΡΠ°ΡΡ ΡΠ΅ΡΠ΅ΠΏΡ
3176
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